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September 12, 2014
NIH awards aim to improve understanding of cell pathways, development of new therapies
Building on a successful three-year pilot project, the National Institutes of Health has awarded more than $64 million to six research institutions to create a database of human cellular responses, the Library of Integrated Network-based Cellular Signatures (LINCS).  Discovering such cell responses will improve scientists’ understanding of cell pathways and aid in the development of new therapies for many diseases.

September 9, 2014
NIH-convened panel recommends expanded adoption of drug and transfusion treatments for individuals with sickle cell disease
An expert panel has recommended expanded adoption of the drug hydroxyurea for the care of people with sickle cell disease, according to a report issued today. The report also suggests that clinicians give periodic blood transfusions to children with the disease to reduce stroke risk. According to the panel, both treatments are underutilized.

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Spotlight On Research

Featured Fact Sheet

images of the reduction in blood flow after a mental stress test compared to after a physical stress test and at rest

Emotional stress and heart disease in women: an interview with Dr. Viola Vaccarino
When it comes to the effects of emotional stress on the heart, young men and women may not be created equal. Understanding the role of emotional factors—in particular psychological stress—on heart disease risk is a professional passion for longtime NHLBI grantee, Dr. Viola Vaccarino, a leader in women’s health research. Read full fact sheet...

NHLBI In The News rss feed

September 25, 2014 : Health News Digest
UCLA Scientists Unlock Protein that Can Accelerate Recovery in Cancer Patients Following Radiation and Chemotherapy
Scientists from UCLA's Jonsson Comprehensive Cancer Center (JCCC) have shown for the first time how a unique protein found in human bone marrow can drive stem cells to repair our blood system after an injury. These groundbreaking findings provide a roadmap to make existing radiation and chemotherapy treatments more effective for patients with cancer and other blood-related diseases. This research was funded in part by the NHLBI.

September 25, 2014 : CTSI Discovery Radio
CTSI Discovery Radio Living with Sickle Cell Disease
Each day, more than 100,000 people suffer from a chronic, genetic blood disease that causes debilitating pain. This episode of CTSI Discovery Radio discusses new ways people living with Sickle Cell Disease are finding some relief right through new clinical trials, a medical home for Sickle Cell patients, and new guidelines to help lower the risk of the disease causing a crisis in patients it affects. This segment features NHLBI's Dr. Keith Hoots.

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Director's Message
Researcher Brings Medicine One Step Closer to Widely Available Cure for Sickle Cell Disease

Gary H. Gibbons
September 2, 2014

From the use of antibiotics to prevent and treat infections in children with sickle cell disease to the FDA approval of the drug hydroxyurea, researchers have made steady progress during the last few decades in improving the lives of individuals with sickle cell disease. Yet still, a widely available cure has remained just out of reach. Now, work from a team of researchers at the National Institutes of Health, including NHLBI’s Dr. John Tisdale may open the door to reversing sickle cell disease in more patients....
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